Phytochemical and wound healing potential of ethanolic extract of Nymphaea alba

Abstract

The present study evaluates the effectiveness of the ethanolic extract of Nymphaea alba in wound healing and administers phytochemicals using "an excision and incision wound model on Wistar strain albino rats". Plant extracts have a higher phytoconstituent concentration, according to “phytochemical screening”. "Phenolic compounds, alkaloids, carbohydrates, flavonides, glycosides, and tannin" were all detected in the ethanolic extract of Nymphaea alba. "The tensile strength of the healed wounds" was assessed using the incision wound model, and the influence of wound healing was assessed using the excision wound model, which took into consideration the epithelialisation time and the percentage of wound closure. Wistar albino rats' dorsal surfaces were subjected to excision and incision wounds. Four groups of six rats each were randomly selected from among them. Group I served as the control group, receiving no treatment other than a basic ointment. Group II was used with framycetin sulphate cream (Soframycin, Aventis) and was regarded as the standard group. Group III was given EENA 2% (w/w), while Group IV was given EENA 5% (w/w). These were considered test groups. Compared to the usual control group, Nymphaea alba significantly rises the percentage of wound contraction, reduces its duration of epithelialisation, and increases the tensile strength of the skin in all forms. In view of the positive results, it may be feasible to conduct additional research to evaluate the efficacy of various wound models.