Development and Characterization of Crisaborole-Loaded Liposomal Drug Delivery System for Enhanced Topical and Antibacterial

Prabhat Yadav; Brajesh Kumar Arjariya; Praveen Bhawsar

doi:10.69968/ijisem.2026v5i261-73

Authors

Prabhat Yadav Research Scholar, Department of M. Pharma (Pharmaceutics), Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)
Brajesh Kumar Arjariya Professor, Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)
Praveen Bhawsar Associate Professor, Department of M. Pharma (Pharmaceutics), Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)

DOI:

https://doi.org/10.69968/ijisem.2026v5i261-73

Keywords:

Crisaborole, Liposphere formulation, Thin-film hydration, Entrapment efficiency, Antibacterial activity

Abstract

The present study focuses on the preparation, development, and characterization of a liposphere formulation containing Crisaborole to enhance its solubility, dermal delivery, and antibacterial efficacy. The formulation was developed using the thin-film hydration method with soya lecithin. Pre-formulation studies confirmed suitable physicochemical properties, with a melting point of 131°C, pH 5.3, and λmax at 250 nm, showing good linearity (R² = 0.9951). The optimized formulation exhibited a particle size of 43.07 nm, zeta potential of -18.0 mV, and high entrapment efficiency (93.48%), indicating stability and uniformity. SEM analysis confirmed spherical morphology. In-vitro drug release followed zero-order and Higuchi kinetics, suggesting controlled diffusion. Stability studies demonstrated minimal changes under refrigerated conditions. The formulation showed enhanced antibacterial activity against Staphylococcus aureus and E. coli compared to the pure drug. Overall, the developed liposphere system proved to be a promising approach for improved topical delivery and therapeutic effectiveness of Crisaborole.

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