Preparation and Characterization of Fenoprofen Liposomes for Controlled Drug Delivery Applications

Jitendra Yadav; Brajesh Kumar Arjariya; Praveen Bhawsar

doi:10.69968/ijisem.2026v5i288-99

Authors

Jitendra Yadav Research Scholar, Department of M. Pharma (Pharmaceutics), Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)
Brajesh Kumar Arjariya Professor, Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)
Praveen Bhawsar Associate Professor, Department of M. Pharma (Pharmaceutics), Malhotra College of Pharmacy, Badwai, Near Karond, Bhopal (M.P.)

DOI:

https://doi.org/10.69968/ijisem.2026v5i288-99

Keywords:

Liposomal Drug Delivery System, Fenoprofen HCl, Thin Film Hydration Technique, In Vitro Drug Release, Zeta Potential and Stability Analysis

Abstract

The present study focuses on the formulation and evaluation of a liposomal drug delivery system for Fenoprofen HCl to enhance therapeutic efficacy and reduce associated toxicities. Preformulation studies, including organoleptic evaluation, solubility, melting point, partition coefficient, and λmax determination (270.8 nm), were carried out to establish the physicochemical properties of the drug. Compatibility studies using FTIR confirmed the absence of interactions between the drug and excipients. Liposomes were prepared by the thin film hydration technique using soybean lecithin and stabilizers such as dicetylphosphate and stearylamine. The formulated liposomes were evaluated for particle size, zeta potential, surface morphology, drug entrapment, in vitro drug release, and stability. Among all formulations, F6 exhibited optimal particle size, higher stability (zeta potential −23.4 mV), and sustained drug release behavior. SEM analysis confirmed smooth and uniform vesicle morphology. In vitro release studies indicated controlled drug release following zero-order kinetics and Case II transport mechanism. Stability studies demonstrated that the formulations remained stable over 60 days. Overall, the developed liposomal formulation of Fenoprofen showed improved stability, controlled drug release, and potential for effective management of pain and inflammatory conditions such as osteoarthritis and rheumatoid arthritis.

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