Leech Therapy: An Old Method Applied in Modern Medicine

Authors

  • Malsoor Thirumala Assistant professor of Zoology, Government Arts & Science College (A), Kamareddy, Telangana, India.
  • K. Vanaja Degree Lecturer of Zoology, Telangana Social Welfare Residential Degree College for Women-Kamareddy, Telangana, India

DOI:

https://doi.org/10.69968/ijisem.2026v5i2112-115

Keywords:

Leech therapy, Bloodletting, Pain management, Antithrombotic agents, Wound healing

Abstract

Leech therapy, also known as hirudotherapy, originated in ancient medicine when people used leeches for therapeutic purposes. Different cultures around the world have found these blood-draining, wormlike creatures since antiquity. In leech saliva, enzymes, peptides, and proteins such as anticoagulants, vasodilators, anti-inflammatory, and anaesthetic substances are present. Hirudin, an anticoagulant that prevents blood clotting, is the most important agent in leech saliva. In the 19th century, other bloodletting methods, whose origins date back even further than leech therapy, found their "application" in the "medicinal setting" of leech therapy. Consequently, "therapeutic bloodletting" gained popularity, particularly in Europe. However, plastic and reconstructive surgery, dermatology, and the management of pain/discomfort have been the primary areas where leech therapy has gained popularity in recent years. However, the historical limitations of leech therapy necessitate the performance of trained healthcare professionals.

References

[1] Ansari S, Nil F, Jabeen A, Sultana A, Khan QA. Post-auricular leech therapy reduced headache & migraine days in chronic migraine. J Drug Deliv Ther. (2019) 9:75–80. doi:10.22270/jddt.v9i1-s.23452.

[2] Alemi F, Azimi M, Moeini R, Shirafkan H, Bayani M, Mojahedi M, et al. Theeffectiveness of leech therapy in the severity of diabetic neuropathy: a randomizedcontrolled trial. Tradit Integr Med. (2022) 2022:11488. doi: 10.18502/tim.v7i4.114883.

[3] Singh SK, Rajoria K. Medical leech therapy in Ayurveda and biomedicine–a review.J Ayurveda Integr Med. (2020) 11:554–64. doi: 10.1016/j.jaim.2018.09.003

[4] Hyson JM. Leech therapy: a history. J Hist Dent.2005;53(1):25–7.2.

[5] Munshi Y, Ara I, Rafique H, Ahmad Z. Leeching in the his-tory. Pak J Biol Sci. 2008;11:1650–3.3.

[6] Whitaker IS, Rao J, Izadi D, Butler PE. Historical article: Hirudo medicinalis: ancient origins of, and trends in the useof medicinal leeches throughout history. Br J Oral Maxil-lofac Surg. 2004;42:133–7

[7] Petrauskiene L, Utevska O, Utevsky S. Reproduc-tion biology and ecological strategies of three spe-cies of medicinal leeches (genus Hirudo). J Nat Hist.2011;45(11–12):737–47.5.

[8] Hildebrandt JP, Lemke S. Small bite, large impact-salivaand salivary molecules in the medicinal leech, Hirudomedicinalis. Natur wissenschaften. 2011;98:995–1008.

[9] Baskova IP, Zavalova LL, Basanova AV, Moshkovskii SA,Zgoda VG. Protein profiling of the medicinal leech salivary gland secretion by proteomic analytical methods. Bio-chemistry. 2004;69(7):770–5.

[10] Yanes O, Villanueva J, Querol E, Aviles FX. Functional screening of serine protease inhibitors in the medicinal leech Hirudo medicinalis monitored by intensity fading MALDI-TOF MS. Mol cell Proteomics. 2005;4:1602–13.

[11] Baskova IP, Zavalova LL. Proteinase inhibitors from the medicinal leech Hirudo medicinalis. Biochemistry.2001;66(12):869–83.10. Michalsen A, Roth M. Blutegeltherapie. Stuttgart: Haug;2012.

[12] Clarke CEW. Medical therapeutics derived from leeches (phy. Annelida; cl.Hirudinea). Macewan Univ Student EJ. (2016) 3:297. doi: 10.31542/j.muse.297

[13] Barzegar A, Azizi A, Faridi P, Mohagheghzadeh A. Leech therapy in Iranian traditional medicine. Complement Med Res. (2015) 22:50–3. doi: 10.1159/000377690

[14] Sig AK, Guney M, Guclu AU, Ozmen E. Medicinal leech therapy—an overall perspective. Integr Med Res. (2017) 6:337–43. doi: 10.1016/j.imr.2017.08.001

[15] Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. (2009)151:264. doi: 10.7326/0003-4819-151-4-200908180-00135

[16] Some HH, Some L. Revised Cochrane risk-of-bias tool for randomized trials (RoB 2).

Downloads

Published

23-04-2026

Issue

Section

Articles

How to Cite

[1]
Malsoor Thirumala and K. Vanaja 2026. Leech Therapy: An Old Method Applied in Modern Medicine. International Journal of Innovations in Science, Engineering And Management. 5, 2 (Apr. 2026), 112–115. DOI:https://doi.org/10.69968/ijisem.2026v5i2112-115.